XBP1

Across TCGA patient cohorts, XBP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,298 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible XBP1-associated proteins across cancer lineages are NUCB2, SEC23B, and DNAJC1. Each is linked with XBP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both XBP1-to-partner and partner-to-XBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XBP1 versus NUCB2 in UCEC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XBP1→partner) and Y-score (partner→XBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUCB2 →	+0.645	+1.077	<.001	<.001	3	8
HNSC	SEC23B →	+0.496	+1.357	<.001	<.001	3	8
BRCA	DNAJC1 →	+0.616	+1.587	.001	<.001	3	8
BRCA	HID1 →	+0.780	+1.680	<.001	<.001	3	8
LSCC	GMPPA →	+0.430	+0.952	<.001	<.001	3	8
LSCC	SDF2L1 →	+0.474	+0.794	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,298 associations by consensus.

XBP1 vs NUCB2 — UCEC

Explore this scatter interactively →