XBP1

Across TCGA patient cohorts, XBP1 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XBP1-associated genes across cancer lineages are CD4+ Tem, CMP, and Erythrocytes. Each is linked with XBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XBP1-to-partner and partner-to-XBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tem grouped by XBP1-low versus XBP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XBP1→partner) and Y-score (partner→XBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CD4+ Tem →	+0.034	+5.624	<.001	.039	3	1
UCEC	CMP →	+0.048	+2.828	.002	.035	3	1
UCEC	Erythrocytes →	+0.042	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD4+ Tem by XBP1 expression — SKCM

Explore this box plot interactively →