XAGE3

Across TCGA patient cohorts, XAGE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,671 significant associations in total. COAD shows the largest number of these associations.

The most reproducible XAGE3-associated GO terms across cancer lineages are Mitochondrial respiratory chain complex assembly, Thioester metabolic process, and Spliceosomal conformational changes to generate catalytic conformation. Each is linked with XAGE3 in more than 8 cancer types. Because this analysis shows association rather than direction, both XAGE3-to-partner and partner-to-XAGE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial respiratory chain complex assembly grouped by XAGE3-low versus XAGE3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XAGE3→partner) and Y-score (partner→XAGE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Mitochondrial respiratory chain complex assembly →	+0.065	+0.143	<.001	<.001	3	9
STAD	Thioester metabolic process →	+0.047	+0.106	<.001	.001	2	8
READ	Spliceosomal conformational changes to generate catalytic conformation →	+0.031	+0.113	<.001	<.001	3	7
STAD	Mitochondrial translation →	+0.064	+0.185	<.001	.001	2	7
ESCA	2-oxoglutarate metabolic process →	+0.056	+0.078	<.001	.005	2	7
STAD	Outer mitochondrial membrane organization →	+0.045	+0.147	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,671 associations by consensus.

Mitochondrial respiratory chain complex assembly by XAGE3 expression — STAD

Explore this box plot interactively →