XAGE3

Across TCGA cell cohorts, XAGE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 489 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XAGE3-associated GO terms across cancer lineages are Negative regulation of chaperone-mediated autophagy, Lateral mesoderm development, and Neuropeptide signaling pathway. Each is linked with XAGE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both XAGE3-to-partner and partner-to-XAGE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chaperone-mediated autophagy grouped by XAGE3-low versus XAGE3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XAGE3→partner) and Y-score (partner→XAGE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of chaperone-mediated autophagy →	+0.136	+0.076	.006	.006	3	3
BLOOD_Leukemia	Lateral mesoderm development →	-0.136	-0.031	<.001	<.001	3	3
BLOOD_Leukemia	Neuropeptide signaling pathway →	-0.049	-0.030	.003	<.001	3	3
SOFT_TISSUE	Chemotaxis →	+0.077	+0.068	<.001	.006	3	2
SOFT_TISSUE	Nuclear RNA surveillance →	-0.057	-0.072	.001	.007	2	3
LIVER	Negative regulation of NLRP3 inflammasome complex assembly →	+0.083	+0.067	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 489 associations by consensus.

Negative regulation of chaperone-mediated autophagy by XAGE3 expression — LIVER

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