XAF1

Across TCGA pan-cancer cohorts, XAF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated XAF1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher XAF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated XAF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where XAF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.762	1.000	.011	15	view →
COAD	DFS	Median	All	0.862	1.000	.022	12	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	7	view →
LSCC	DFS	Median	II,III,IV	1.000	0.419	.008	6	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →
GBM	OS	Quartile	All	0.978	0.761	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

XAF1–CCRCC (DFS)

Open the CCRCC breakdown →