XAF1

Across TCGA patient cohorts, XAF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,363 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XAF1-associated proteins across cancer lineages are STAT1, STAT2, and TRIM21. Each is linked with XAF1 in more than 9 cancer types. Because this analysis shows association rather than direction, both XAF1-to-partner and partner-to-XAF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XAF1 versus STAT1 in LSCC, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XAF1→partner) and Y-score (partner→XAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAT1 →	+0.702	+1.236	<.001	<.001	3	10
HNSC	STAT2 →	+0.459	+0.916	<.001	<.001	3	10
HNSC	TRIM21 →	+0.553	+0.737	<.001	<.001	3	10
HNSC	TRIM22 →	+0.634	+0.901	<.001	<.001	3	10
HNSC	CMPK2 →	+0.788	+1.107	<.001	<.001	3	10
HNSC	DDX58 →	+0.894	+1.025	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,363 associations by consensus.

XAF1 vs STAT1 — LSCC

Explore this scatter interactively →