XAF1

Across TCGA cell cohorts, XAF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,660 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible XAF1-associated GO terms across cancer lineages are Intracellular receptor signaling pathway, Negative regulation of viral genome replication, and Negative regulation of immune response. Each is linked with XAF1 in more than 16 cancer types. Because this analysis shows association rather than direction, both XAF1-to-partner and partner-to-XAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular receptor signaling pathway grouped by XAF1-low versus XAF1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XAF1→partner) and Y-score (partner→XAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Intracellular receptor signaling pathway →	+0.074	+3.298	.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.203	+3.187	<.001	<.001	3	17
BREAST	Negative regulation of immune response →	+0.096	+2.213	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cytokine-mediated signaling pathway →	+0.112	+2.540	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.103	+3.104	<.001	<.001	3	16
OESOPHAGUS	Positive regulation of response to cytokine stimulus →	+0.143	+1.967	<.001	.005	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,660 associations by consensus.

Intracellular receptor signaling pathway by XAF1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →