XAF1

Across TCGA cell cohorts, XAF1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible XAF1-associated genes across cancer lineages are NPHS2, BMP15, and KRTAP3-3. Each is linked with XAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XAF1-to-partner and partner-to-XAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by XAF1-low versus XAF1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XAF1→partner) and Y-score (partner→XAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NPHS2 →	+0.031	+5.169	<.001	.001	3	1
BLOOD_Lymphoma	BMP15 →	+0.021	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP3-3 →	+0.045	+5.247	<.001	.001	3	1
LUNG_NSCLC_LUAD	PRR23B →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	TMEM207 →	+0.108	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.053	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

NPHS2 by XAF1 expression — BLOOD_Lymphoma

Explore this box plot interactively →