WWTR1

Across TCGA pan-cancer cohorts, WWTR1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WWTR1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WWTR1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WWTR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where WWTR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.290	0.529	.004	20	view →
LSCC	OS	Median	All	0.920	1.000	.008	19	view →
HNSC	DFS	Median	All	0.993	0.915	.011	10	view →
CCRCC	DFS	Median	All	0.650	0.827	.017	6	view →
GBM	OS	Quartile	All	0.717	0.909	.009	4	view →
LUAD	DFS	Quartile	All	0.895	0.430	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WWTR1–PDAC (OS)

Open the PDAC breakdown →