WWTR1

Across TCGA patient cohorts, WWTR1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,769 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WWTR1-associated genes across cancer lineages are COMMD2, WWTR1-IT1, and MYL9. Each is linked with WWTR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both WWTR1-to-partner and partner-to-WWTR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WWTR1 versus COMMD2 in LSCC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWTR1→partner) and Y-score (partner→WWTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COMMD2 →	+0.621	+0.429	<.001	<.001	3	6
LSCC	WWTR1-IT1 →	+0.907	+0.415	<.001	<.001	3	6
OV	MYL9 →	+1.192	+0.549	<.001	.001	3	5
UCEC	ACTA2 →	+1.085	+0.237	.002	.009	3	5
BRCA	SPARC →	+1.086	+0.371	<.001	<.001	3	5
LSCC	ACVR1 →	+0.508	+0.346	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,769 associations by consensus.

WWTR1 vs COMMD2 — LSCC

Explore this scatter interactively →