WWTR1

Across TCGA patient cohorts, WWTR1 mutation is significantly associated with the RNA expression of many other genes, with 1,261 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWTR1-associated genes across cancer lineages are SNORD115-2, RNU1-130P, and RN7SL722P. Each is linked with WWTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WWTR1-to-partner and partner-to-WWTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-2 grouped by WWTR1-low versus WWTR1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWTR1→partner) and Y-score (partner→WWTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNORD115-2 →	+0.501	+7.930	<.001	.008	3	2
LUAD	RNU1-130P →	+0.298	+7.930	<.001	.008	3	2
BRCA	RN7SL722P →	+0.189	+8.471	<.001	.005	3	1
BLCA	TAAR6 →	+0.085	+5.603	<.001	<.001	3	1
BLCA	OR56B3P →	+0.076	+3.719	<.001	.008	3	1
BLCA	POM121L1P →	+0.039	+4.558	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,261 associations by consensus.

SNORD115-2 by WWTR1 expression — LUAD

Explore this box plot interactively →