WWTR1

Across TCGA patient cohorts, WWTR1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWTR1-associated genes across cancer lineages are HER3, JNK2, and Rad50. Each is linked with WWTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WWTR1-to-partner and partner-to-WWTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by WWTR1-low versus WWTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWTR1→partner) and Y-score (partner→WWTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	-0.274	-2.990	.032	.036	3	1
UCEC	JNK2 →	+0.202	+2.179	.029	.034	3	1
UCEC	Rad50 →	-0.247	-3.156	.028	.018	3	1
UCEC	VHL →	-0.877	-2.321	.005	.034	3	1
UCEC	ARID1A →	-0.211	-2.989	.016	.035	2	1
UCEC	Caspase-8 →	-0.308	-2.584	.008	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

HER3 by WWTR1 expression — UCEC

Explore this box plot interactively →