WWTR1

Across TCGA cell cohorts, WWTR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,907 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible WWTR1-associated GO terms across cancer lineages are Regulation of protein localization to early endosome, Positive regulation of protein localization to early endosome, and Potassium ion transmembrane transport. Each is linked with WWTR1 in more than 12 cancer types. Because this analysis shows association rather than direction, both WWTR1-to-partner and partner-to-WWTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to early endosome grouped by WWTR1-low versus WWTR1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WWTR1→partner) and Y-score (partner→WWTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of protein localization to early endosome →	+0.230	+2.422	<.001	<.001	3	13
LIVER	Positive regulation of protein localization to early endosome →	+0.230	+2.422	<.001	<.001	3	13
STOMACH	Potassium ion transmembrane transport →	-0.083	-3.441	.001	<.001	3	13
BREAST	Regulation of cell-matrix adhesion →	+0.121	+2.053	<.001	<.001	3	13
BREAST	Regulation of ERBB signaling pathway →	+0.067	+1.672	<.001	<.001	3	12
BREAST	Viral life cycle →	+0.097	+2.537	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,907 associations by consensus.

Regulation of protein localization to early endosome by WWTR1 expression — LIVER

Explore this box plot interactively →