Across TCGA patient cohorts, WWP2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WWP2-associated genes across cancer lineages are p27_pT198, STAT5a, and Smad3. Each is linked with WWP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both WWP2-to-partner and partner-to-WWP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWP2→partner) and Y-score (partner→WWP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.072	+1.064	.027	.048	3	3
UCEC	STAT5a →	+0.312	+1.064	.010	.048	3	3
SKCM	Smad3 →	+0.167	+2.115	.015	.018	3	3
STAD	Annexin-1 →	+0.676	+3.021	<.001	.018	3	2
STAD	Chk1 →	+0.342	+3.000	.002	.036	2	3
UCEC	ERK2 →	+0.179	+2.999	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

WWP2 survival (RNA) · tumor vs normal (RNA) · all WWP2 data types