WWP1

Across TCGA pan-cancer cohorts, WWP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WWP1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WWP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WWP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where WWP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.669	0.264	.006	25	view →
CCRCC	DFS	Tertile	III,IV	0.224	0.655	.001	14	view →
HNSC	OS	Median	II,III,IV	0.916	0.772	.004	11	view →
GBM	DFS	Median	All	0.829	0.659	.023	5	view →
LSCC	DFS	Tertile	III,IV	1.000	0.519	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WWP1–PDAC (OS)

Open the PDAC breakdown →