WWP1

Across TCGA cell cohorts, WWP1 mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWP1-associated genes across cancer lineages are FRA10AC1, SFTPB, and BTBD16. Each is linked with WWP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WWP1-to-partner and partner-to-WWP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FRA10AC1 grouped by WWP1-low versus WWP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWP1→partner) and Y-score (partner→WWP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FRA10AC1 →	+0.467	+2.502	.009	.005	3	2
LARGE_INTESTINE	SFTPB →	+0.148	+2.548	<.001	.001	3	2
BLOOD_Leukemia	BTBD16 →	+0.061	+3.281	.001	.003	3	1
BLOOD_Leukemia	CYP39A1 →	+0.146	+3.091	<.001	.006	3	1
BLOOD_Leukemia	PCDH19 →	+0.205	+3.540	<.001	.005	3	1
BLOOD_Leukemia	UCMA →	+0.050	+2.926	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

FRA10AC1 by WWP1 expression — LARGE_INTESTINE

Explore this box plot interactively →