WWOX-AS1

Across TCGA pan-cancer cohorts, WWOX-AS1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated WWOX-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher WWOX-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated WWOX-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BLCA show a favorable association.

LUAD, UVM, and SKCM are the cancer types where WWOX-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.555	0.248	.003	57	view →
UVM	OS	Tertile	All	0.218	0.696	.014	48	view →
SKCM	OS	Tertile	III,IV	0.195	0.738	<.001	42	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
BLCA	OS	Tertile	IV	0.507	0.239	.031	21	view →
CESC	OS	Tertile	All	0.699	0.544	.038	18	view →
OV	DFS	Quartile	IV	0.328	0.583	.014	18	view →
KIRC	DFS	Tertile	III,IV	0.856	0.683	.029	10	view →
MESO	OS	Tertile	IV	1.000	0.318	.048	6	view →
READ	OS	Tertile	II,III,IV	0.249	0.705	.041	6	view →
THCA	DFS	Tertile	IV	0.703	0.896	.040	3	view →
LUSC	OS	Tertile	II,III,IV	0.522	0.808	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

WWOX-AS1–LUAD (OS)

Open the LUAD breakdown →