WWC3

Across TCGA patient cohorts, WWC3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,048 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WWC3-associated genes across cancer lineages are CLNS1A, GJA5, and ACTA2. Each is linked with WWC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both WWC3-to-partner and partner-to-WWC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WWC3 versus CLNS1A in LSCC, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC3→partner) and Y-score (partner→WWC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLNS1A →	-0.673	-0.229	<.001	<.001	3	4
LSCC	GJA5 →	+0.933	+0.266	<.001	<.001	3	4
UCEC	ACTA2 →	+1.493	+0.275	.001	.005	3	4
UCEC	ADGRD1 →	+1.224	+0.269	<.001	<.001	3	4
BRCA	SPARC →	+0.971	+0.303	<.001	<.001	3	4
BRCA	PDGFRB →	+1.096	+0.346	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,048 associations by consensus.

WWC3 vs CLNS1A — LSCC

Explore this scatter interactively →