WWC3

Across TCGA patient cohorts, WWC3 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. COAD shows the largest number of these associations.

The most reproducible WWC3-associated genes across cancer lineages are eIF4E, Rad50, and RAD51. Each is linked with WWC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both WWC3-to-partner and partner-to-WWC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by WWC3-low versus WWC3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC3→partner) and Y-score (partner→WWC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.188	+1.700	.006	.042	3	4
COAD	Rad50 →	-0.478	-2.974	<.001	<.001	3	4
COAD	RAD51 →	+0.215	+1.593	<.001	.022	3	4
COAD	c-Kit →	-0.725	-3.321	<.001	.009	3	3
COAD	MSH2 →	-0.180	-1.576	.022	.035	3	3
COAD	PDCD4 →	-0.342	-1.576	.021	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

eIF4E by WWC3 expression — STAD

Explore this box plot interactively →