WWC3

Across TCGA cell cohorts, WWC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,921 significant associations in total. CNS shows the largest number of these associations.

The most reproducible WWC3-associated GO terms across cancer lineages are Regulation of translational initiation, Endosomal transport, and Macroautophagy. Each is linked with WWC3 in more than 15 cancer types. Because this analysis shows association rather than direction, both WWC3-to-partner and partner-to-WWC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational initiation grouped by WWC3-low versus WWC3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC3→partner) and Y-score (partner→WWC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of translational initiation →	+0.077	+0.848	.006	.007	3	16
OESOPHAGUS	Endosomal transport →	+0.055	+1.045	.003	.005	3	14
STOMACH	Macroautophagy →	+0.093	+2.112	<.001	<.001	3	13
STOMACH	Vesicle-mediated transport to the plasma membrane →	+0.082	+2.152	<.001	<.001	3	13
BREAST	Golgi vesicle transport →	+0.066	+1.573	<.001	<.001	3	12
STOMACH	Process utilizing autophagic mechanism →	+0.095	+1.817	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,921 associations by consensus.

Regulation of translational initiation by WWC3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →