WWC3

Across TCGA cell cohorts, WWC3 mutation is significantly associated with the RNA expression of many other genes, with 587 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WWC3-associated genes across cancer lineages are KCNK16, DEFB132, and F9. Each is linked with WWC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WWC3-to-partner and partner-to-WWC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK16 grouped by WWC3-low versus WWC3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WWC3→partner) and Y-score (partner→WWC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KCNK16 →	+0.051	+3.930	<.001	.003	3	2
STOMACH	DEFB132 →	+0.113	+5.285	<.001	.003	3	1
LUNG_SCLC	F9 →	+0.036	+5.643	<.001	.002	3	1
LUNG_SCLC	IL36A →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	OR7G3 →	+0.063	+5.643	<.001	.002	3	1
LUNG_SCLC	FFAR3 →	+0.058	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 587 associations by consensus.

KCNK16 by WWC3 expression — SKIN

Explore this box plot interactively →