Across TCGA patient cohorts, WT1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WT1-associated proteins across cancer lineages are GFPT2_T227, FLNC, and PTGIS. Each is linked with WT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both WT1-to-partner and partner-to-WT1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WT1→partner) and Y-score (partner→WT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GFPT2_T227 →	+1.617	+0.948	<.001	.004	3	7
HNSC	FLNC →	+1.096	+0.233	<.001	.004	3	5
UCEC	PTGIS →	+0.761	+1.162	<.001	<.001	3	5
COAD	OMD →	+1.246	+0.921	.001	.003	3	5
LSCC	ARMCX1 →	+0.674	+0.663	<.001	<.001	3	4
UCEC	RECK →	+0.409	+1.368	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,620 associations by consensus.

Exploration

WT1 survival (RNA) · tumor vs normal (RNA) · all WT1 data types