Across TCGA patient cohorts, WT1 mutation is significantly associated with the RNA expression of many other genes, with 4,321 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WT1-associated genes across cancer lineages are AP1S3, ATP1B2, and RNU6-207P. Each is linked with WT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both WT1-to-partner and partner-to-WT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WT1→partner) and Y-score (partner→WT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP1S3 →	+0.765	+2.874	<.001	<.001	3	4
UCEC	ATP1B2 →	-0.747	-4.159	<.001	<.001	3	4
HNSC	RNU6-207P →	+0.339	+5.608	<.001	.002	3	3
UCEC	TSPAN7 →	-1.221	-2.311	<.001	<.001	3	3
UCEC	CCNB2 →	+0.619	+2.000	.001	.001	3	3
UCEC	PBK →	+0.832	+3.700	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,321 associations by consensus.

Exploration

WT1 survival (RNA) · tumor vs normal (RNA) · all WT1 data types