Across TCGA patient cohorts, WT1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WT1-associated genes across cancer lineages are MIG-6, ASNS, and C-Raf. Each is linked with WT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both WT1-to-partner and partner-to-WT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WT1→partner) and Y-score (partner→WT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIG-6 →	+0.325	+2.824	.003	.034	3	3
COAD	ASNS →	+0.630	+1.882	<.001	.031	3	3
COAD	C-Raf →	+0.180	+2.593	.003	.006	3	3
COAD	PDK1_pS241 →	-0.299	-2.309	<.001	.033	3	2
COAD	XBP1 →	+0.210	+1.882	.008	.031	3	2
UCEC	GAPDH →	+0.433	+1.440	.019	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

WT1 survival (RNA) · tumor vs normal (RNA) · all WT1 data types