Across TCGA cell cohorts, WT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,867 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WT1-associated GO terms across cancer lineages are Negative regulation of female gonad development, Negative regulation of gonad development, and Mesenchymal to epithelial transition. Each is linked with WT1 in more than 12 cancer types. Because this analysis shows association rather than direction, both WT1-to-partner and partner-to-WT1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WT1→partner) and Y-score (partner→WT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of female gonad development →	+1.278	+1.933	<.001	<.001	3	13
BLOOD_Leukemia	Negative regulation of gonad development →	+1.469	+2.093	<.001	<.001	3	10
URINARY_TRACT	Mesenchymal to epithelial transition →	-0.259	-1.223	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.061	+0.736	.002	.002	2	8
OESOPHAGUS	Nucleotide biosynthetic process →	+0.061	+0.861	.002	.009	3	7
OVARY	Ribonucleotide biosynthetic process →	+0.074	+2.265	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,867 associations by consensus.

Exploration

WT1 survival (RNA) · tumor vs normal (RNA) · all WT1 data types