Across TCGA cell cohorts, WT1 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WT1-associated genes across cancer lineages are IFNL4, POM121L12, and ADIG. Each is linked with WT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WT1-to-partner and partner-to-WT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WT1→partner) and Y-score (partner→WT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IFNL4 →	+0.021	+4.191	.001	.007	3	2
LUNG_NSCLC_LUAD	POM121L12 →	+0.022	+5.266	<.001	.001	3	1
LARGE_INTESTINE	ADIG →	+0.031	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CT45A6 →	+0.042	+5.415	<.001	.004	3	1
CNS	HELT →	+0.041	+5.321	<.001	.005	3	1
BLOOD_Leukemia	GML →	+0.060	+2.567	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

Exploration

WT1 survival (RNA) · tumor vs normal (RNA) · all WT1 data types