Across TCGA cell cohorts, WT1 mutation is significantly associated with the mutation status of many other genes, with 1,911 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WT1-associated genes across cancer lineages are MGA, PEG3, and CCDC73. Each is linked with WT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both WT1-to-partner and partner-to-WT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WT1→partner) and Y-score (partner→WT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MGA →	+3.117	+4.491	.004	.004	1	5
STOMACH	PEG3 →	+2.942	+4.025	.009	.009	1	4
BLOOD_Leukemia	CCDC73 →	+4.665	+3.157	.003	.003	1	3
CNS	STYXL2 →	+6.044	+6.044	.001	.001	1	3
CNS	ZNF234 →	+4.459	+5.277	.005	.005	1	3
BREAST	UPF1 →	+4.297	+4.857	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,911 associations by consensus.

Exploration

WT1 survival (RNA) · tumor vs normal (RNA) · all WT1 data types