Across TCGA pan-cancer cohorts, WT1-AS RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of WT1-AS’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WT1-AS RNA is repressed in tumor relative to normal tissue. In most cancer types WT1-AS is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and KIRP are the cancer types where WT1-AS tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WT1-AS RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.