WSB1

Across TCGA cell cohorts, WSB1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WSB1-associated genes across cancer lineages are TBC1D21, PYDC2, and GPR31. Each is linked with WSB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WSB1-to-partner and partner-to-WSB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by WSB1-low versus WSB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WSB1→partner) and Y-score (partner→WSB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1
SKIN	GPR31 →	+0.006	+5.415	<.001	.004	3	1
SKIN	KRTAP2-4 →	+0.034	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TBC1D21 by WSB1 expression — LARGE_INTESTINE

Explore this box plot interactively →