WRN

Across TCGA pan-cancer cohorts, WRN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WRN data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher WRN mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WRN expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where WRN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.521	0.968	.011	23	view →
HNSC	OS	Quartile	All	0.700	0.928	.005	7	view →
LUAD	OS	Tertile	All	0.604	0.828	.026	6	view →
PDAC	DFS	Median	All	0.398	0.214	.018	6	view →
LSCC	OS	Median	II,III,IV	0.782	0.937	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WRN–CCRCC (OS)

Open the CCRCC breakdown →