WRN

Across TCGA patient cohorts, WRN RNA expression is significantly associated with the protein abundance of many other proteins, with 18,280 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WRN-associated proteins across cancer lineages are CCAR2, ELP3, and SF3B3. Each is linked with WRN in more than 8 cancer types. Because this analysis shows association rather than direction, both WRN-to-partner and partner-to-WRN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WRN versus CCAR2 in HNSC, with a Pearson correlation of 0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WRN→partner) and Y-score (partner→WRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCAR2 →	+0.433	+0.789	<.001	<.001	3	9
COAD	ELP3 →	+0.296	+0.490	<.001	<.001	3	7
GBM	SF3B3 →	+0.172	+0.362	<.001	<.001	3	6
GBM	SNRPD2 →	+0.225	+0.289	<.001	<.001	3	6
HNSC	WRN_S1133 →	+0.754	+0.886	<.001	<.001	3	6
BRCA	XPO7 →	+0.296	+0.407	<.001	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,280 associations by consensus.

WRN vs CCAR2 — HNSC

Explore this scatter interactively →