WRN

Across TCGA patient cohorts, WRN protein abundance is significantly associated with the RNA expression of many other genes, with 7,954 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible WRN-associated genes across cancer lineages are RAD51AP1, ESCO2, and CDCA2. Each is linked with WRN in more than 6 cancer types. Because this analysis shows association rather than direction, both WRN-to-partner and partner-to-WRN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WRN versus RAD51AP1 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRN→partner) and Y-score (partner→WRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAD51AP1 →	+1.121	+0.429	<.001	<.001	3	7
COAD	ESCO2 →	+0.953	+0.379	<.001	<.001	3	7
BRCA	CDCA2 →	+1.430	+0.383	<.001	<.001	3	6
HNSC	TMEM97 →	+1.314	+0.321	<.001	.002	3	5
BRCA	AGPAT5 →	+0.941	+0.356	<.001	<.001	3	5
BRCA	PINX1 →	+0.808	+0.366	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,954 associations by consensus.

WRN vs RAD51AP1 — BRCA

Explore this scatter interactively →