WRN

Across TCGA patient cohorts, WRN mutation is significantly associated with the RNA expression of many other genes, with 3,996 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WRN-associated genes across cancer lineages are DNAJC8, ARF4, and PUDPP1. Each is linked with WRN in more than 2 cancer types. Because this analysis shows association rather than direction, both WRN-to-partner and partner-to-WRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC8 grouped by WRN-low versus WRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRN→partner) and Y-score (partner→WRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNAJC8 →	+0.336	+1.523	<.001	<.001	3	3
UCEC	ARF4 →	+0.494	+1.617	<.001	.002	3	3
HNSC	PUDPP1 →	+0.086	+5.069	.001	.008	3	2
SKCM	BRK1 →	+0.280	+1.813	.003	.002	3	2
SKCM	UBL4A →	+0.290	+1.839	.007	.002	3	2
UCEC	R3HCC1 →	+0.402	+2.271	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,996 associations by consensus.

DNAJC8 by WRN expression — UCEC

Explore this box plot interactively →