WRN

Across TCGA patient cohorts, WRN mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WRN-associated genes across cancer lineages are PI3K-p110-a, PDCD4, and Rictor_pT1135. Each is linked with WRN in more than 2 cancer types. Because this analysis shows association rather than direction, both WRN-to-partner and partner-to-WRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by WRN-low versus WRN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRN→partner) and Y-score (partner→WRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PI3K-p110-a →	+0.128	+2.476	.028	.009	3	3
UCEC	PDCD4 →	-0.416	-2.321	.002	.005	3	2
UCEC	Rictor_pT1135 →	-0.081	-1.584	.005	.008	3	2
UCEC	ASNS →	+0.419	+1.716	<.001	.003	3	2
UCEC	ATM →	-0.547	-1.954	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.428	+1.097	.012	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PI3K-p110-a by WRN expression — SKCM

Explore this box plot interactively →