WRN

Across TCGA cell cohorts, WRN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,754 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WRN-associated GO terms across cancer lineages are Mismatch repair, Regulation of maintenance of sister chromatid cohesion, and Regulation of maintenance of mitotic sister chromatid cohesion. Each is linked with WRN in more than 16 cancer types. Because this analysis shows association rather than direction, both WRN-to-partner and partner-to-WRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mismatch repair grouped by WRN-low versus WRN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WRN→partner) and Y-score (partner→WRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mismatch repair →	+0.101	+0.919	<.001	<.001	3	17
BONE	Regulation of maintenance of sister chromatid cohesion →	+0.114	+0.925	.006	.004	3	17
BONE	Regulation of maintenance of mitotic sister chromatid cohesion →	+0.114	+0.925	.006	.004	3	17
LIVER	T-circle formation →	+0.130	+1.412	<.001	<.001	3	16
LIVER	Telomere maintenance via telomere trimming →	+0.130	+1.412	<.001	<.001	3	16
LIVER	Formation of extrachromosomal circular DNA →	+0.130	+1.412	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,754 associations by consensus.

Mismatch repair by WRN expression — BONE

Explore this box plot interactively →