WRN

Across TCGA cell cohorts, WRN mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WRN-associated genes across cancer lineages are SPANXN2, HEMGN, and SLC17A8. Each is linked with WRN in more than 1 cancer types. Because this analysis shows association rather than direction, both WRN-to-partner and partner-to-WRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPANXN2 grouped by WRN-low versus WRN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRN→partner) and Y-score (partner→WRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SPANXN2 →	+0.105	+4.643	<.001	<.001	3	2
CNS	HEMGN →	+0.014	+3.479	.003	.009	3	2
BLOOD_Lymphoma	SLC17A8 →	+0.030	+4.276	.001	.001	3	1
BLOOD_Lymphoma	OR6B2 →	+0.016	+3.459	.001	.004	3	1
BLOOD_Lymphoma	OVCH1 →	+0.294	+3.321	<.001	.006	3	1
BLOOD_Lymphoma	MBD3L2B →	+0.496	+3.192	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

SPANXN2 by WRN expression — BLOOD_Lymphoma

Explore this box plot interactively →