WRAP73

Across TCGA pan-cancer cohorts, WRAP73 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WRAP73 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WRAP73 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WRAP73 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where WRAP73 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.337	0.561	.008	19	view →
CCRCC	DFS	Quartile	All	1.000	0.551	.002	18	view →
HNSC	DFS	Tertile	II,III,IV	0.888	1.000	.049	1	view →
GBM	DFS	Median	All	0.567	0.821	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WRAP73–PDAC (DFS)

Open the PDAC breakdown →