WRAP73

Across TCGA cell cohorts, WRAP73 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,170 significant associations in total. BONE shows the largest number of these associations.

The most reproducible WRAP73-associated GO terms across cancer lineages are Double-strand break repair, Mitotic sister chromatid segregation, and Coenzyme A biosynthetic process. Each is linked with WRAP73 in more than 13 cancer types. Because this analysis shows association rather than direction, both WRAP73-to-partner and partner-to-WRAP73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair grouped by WRAP73-low versus WRAP73-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WRAP73→partner) and Y-score (partner→WRAP73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Double-strand break repair →	+0.089	+0.830	.006	<.001	3	14
SOFT_TISSUE	Mitotic sister chromatid segregation →	+0.105	+0.736	<.001	<.001	3	14
SOFT_TISSUE	Coenzyme A biosynthetic process →	+0.113	+0.756	<.001	<.001	3	14
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.209	+0.923	<.001	<.001	3	14
SOFT_TISSUE	Sister chromatid segregation →	+0.073	+0.517	<.001	<.001	3	13
SKIN	Negative regulation of mRNA splicing, via spliceosome →	+0.098	+0.627	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,170 associations by consensus.

Double-strand break repair by WRAP73 expression — BONE

Explore this box plot interactively →