WRAP53

Across TCGA pan-cancer cohorts, WRAP53 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WRAP53 data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher WRAP53 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WRAP53 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where WRAP53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.955	0.668	.010	13	view →
CCRCC	OS	Tertile	All	0.931	0.745	.009	13	view →
GBM	DFS	Tertile	All	0.435	0.242	.001	11	view →
HNSC	DFS	Tertile	III,IV	0.904	1.000	.016	9	view →
PDAC	OS	Quartile	III,IV	0.529	0.889	.024	6	view →
LSCC	DFS	Tertile	All	0.547	0.887	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WRAP53–LUAD (OS)

Open the LUAD breakdown →