WRAP53

Across TCGA patient cohorts, WRAP53 mutation is significantly associated with the RNA expression of many other genes, with 990 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WRAP53-associated genes across cancer lineages are RNU6-753P, HNF4GP1, and ZFYVE19. Each is linked with WRAP53 in more than 1 cancer types. Because this analysis shows association rather than direction, both WRAP53-to-partner and partner-to-WRAP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-753P grouped by WRAP53-low versus WRAP53-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRAP53→partner) and Y-score (partner→WRAP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	RNU6-753P →	+0.303	+7.962	<.001	.007	3	2
SARC	HNF4GP1 →	+0.599	+5.380	<.001	.002	3	2
UCEC	ZFYVE19 →	+0.423	+2.098	.001	.003	3	2
LUAD	RN7SL275P →	+0.147	+4.890	<.001	.002	3	2
SARC	MIR6777 →	+0.528	+5.977	<.001	.001	3	2
SKCM	OR7E156P →	+0.617	+2.897	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 990 associations by consensus.

RNU6-753P by WRAP53 expression — THCA

Explore this box plot interactively →