WRAP53

Across TCGA patient cohorts, WRAP53 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WRAP53-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ERK2. Each is linked with WRAP53 in more than 1 cancer types. Because this analysis shows association rather than direction, both WRAP53-to-partner and partner-to-WRAP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by WRAP53-low versus WRAP53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRAP53→partner) and Y-score (partner→WRAP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.105	-2.295	.011	.033	3	1
UCEC	EGFR_pY1068 →	-0.232	-2.321	.025	.034	3	1
UCEC	ERK2 →	+0.159	+2.999	.046	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.107	-2.000	.037	.029	3	1
UCEC	JNK_pT183_Y185 →	-0.159	-1.794	.022	.027	3	1
UCEC	JNK2 →	+0.283	+3.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

14-3-3_beta by WRAP53 expression — UCEC

Explore this box plot interactively →