WRAP53

Across TCGA cell cohorts, WRAP53 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WRAP53-associated genes across cancer lineages are MAGEB4, LMNTD1, and ACCSL. Each is linked with WRAP53 in more than 1 cancer types. Because this analysis shows association rather than direction, both WRAP53-to-partner and partner-to-WRAP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by WRAP53-low versus WRAP53-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WRAP53→partner) and Y-score (partner→WRAP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	LMNTD1 →	+0.217	+3.969	<.001	.002	3	1
LARGE_INTESTINE	ACCSL →	+0.016	+3.688	<.001	.002	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1
SKIN	TPPP2 →	+0.068	+4.217	<.001	.001	3	1
SKIN	CDR1 →	+0.192	+3.920	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MAGEB4 by WRAP53 expression — LARGE_INTESTINE

Explore this box plot interactively →