WNT9B

Across TCGA patient cohorts, WNT9B mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible WNT9B-associated genes across cancer lineages are HER3, FOXO3a, and Paxillin. Each is linked with WNT9B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT9B-to-partner and partner-to-WNT9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by WNT9B-low versus WNT9B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT9B→partner) and Y-score (partner→WNT9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER3 →	+0.460	+3.186	.041	.010	3	2
SKCM	FOXO3a →	-0.139	-3.169	.027	.019	3	1
SKCM	Paxillin →	+0.558	+3.169	.012	.019	3	1
SKCM	Rb_pS807_S811 →	+0.518	+3.169	.028	.019	3	1
SKCM	SCD →	-0.266	-3.169	<.001	.018	2	1
SKCM	Smad3 →	+0.180	+3.169	.038	.019	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

HER3 by WNT9B expression — SKCM

Explore this box plot interactively →