WNT6

Across TCGA cell cohorts, WNT6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,272 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WNT6-associated GO terms across cancer lineages are Regulation of RNA splicing, Meiotic telomere tethering at nuclear periphery, and Meiotic telomere clustering. Each is linked with WNT6 in more than 9 cancer types. Because this analysis shows association rather than direction, both WNT6-to-partner and partner-to-WNT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by WNT6-low versus WNT6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT6→partner) and Y-score (partner→WNT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of RNA splicing →	+0.073	+0.829	.002	.005	3	10
STOMACH	Meiotic telomere tethering at nuclear periphery →	+0.107	+2.780	<.001	<.001	2	10
STOMACH	Meiotic telomere clustering →	+0.107	+2.780	<.001	<.001	2	10
STOMACH	Meiotic attachment of telomere to nuclear envelope →	+0.107	+2.780	<.001	<.001	2	10
STOMACH	Regulation of proteasomal protein catabolic process →	+0.101	+2.696	<.001	<.001	3	9
STOMACH	Regulation of cardiac muscle tissue development →	+1.330	+2.289	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,272 associations by consensus.

Regulation of RNA splicing by WNT6 expression — BONE

Explore this box plot interactively →