WNT6

Across TCGA cell cohorts, WNT6 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WNT6-associated genes across cancer lineages are KRTAP11-1, IL31, and GABRG1. Each is linked with WNT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT6-to-partner and partner-to-WNT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP11-1 grouped by WNT6-low versus WNT6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT6→partner) and Y-score (partner→WNT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP11-1 →	+0.022	+5.415	<.001	.004	3	1
SKIN	IL31 →	+0.028	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GABRG1 →	+0.009	+3.196	.001	.007	3	1
LUNG_NSCLC_LUAD	DEFB134 →	+0.088	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

KRTAP11-1 by WNT6 expression — SKIN

Explore this box plot interactively →