WNT5A-AS1

Across TCGA pan-cancer cohorts, WNT5A-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated WNT5A-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher WNT5A-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated WNT5A-AS1 expression acts as an unfavorable survival marker, although some lineages such as THYM and HNSC show a favorable association.

ACC, LGG, and STAD are the cancer types where WNT5A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.513	0.802	<.001	71	view →
LGG	DFS	Median	All	0.653	0.824	<.001	54	view →
STAD	DFS	Tertile	III,IV	0.251	0.565	.002	46	view →
UVM	OS	Quartile	III,IV	0.231	0.836	.002	36	view →
BLCA	OS	Median	III,IV	0.487	0.665	.003	32	view →
THYM	DFS	Tertile	II,III,IV	0.964	0.735	.004	29	view →
HNSC	DFS	Median	II,III,IV	0.750	0.635	.012	25	view →
SARC	DFS	Median	All	0.369	0.600	.001	22	view →
LUAD	OS	Median	III,IV	0.627	0.333	.006	16	view →
PAAD	OS	Quartile	All	0.301	0.614	.005	14	view →
COAD	OS	Quartile	III,IV	0.865	0.722	.034	11	view →
BRCA	OS	Tertile	All	0.976	0.945	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

WNT5A-AS1–ACC (DFS)

Open the ACC breakdown →