WNT4

Across TCGA pan-cancer cohorts, WNT4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WNT4 data layer compared with 19 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher WNT4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated WNT4 expression acts as an unfavorable survival marker.

OV, COAD, and PRAD are the cancer types where WNT4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	II,III,IV	0.218	0.542	.009	18	view →
COAD	OS	Median	All	0.162	0.674	.007	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

WNT4–OV (DFS)

Open the OV breakdown →