WNT4

Across TCGA pan-cancer cohorts, WNT4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WNT4 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher WNT4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WNT4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where WNT4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.547	0.911	.001	35	view →
HNSC	DFS	Median	All	0.925	0.726	.019	14	view →
PDAC	DFS	Median	IV	0.934	0.236	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

WNT4–LSCC (DFS)

Open the LSCC breakdown →