WNT3

Across TCGA patient cohorts, WNT3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT3-associated genes across cancer lineages are Notch1, MEK1, and MSH6. Each is linked with WNT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT3-to-partner and partner-to-WNT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by WNT3-low versus WNT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT3→partner) and Y-score (partner→WNT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.197	+2.472	<.001	.010	3	2
UCEC	MEK1 →	+0.301	+2.459	.046	.019	3	1
UCEC	MSH6 →	-0.384	-3.321	.004	.009	3	1
UCEC	p62 Lck ligand →	+0.282	+2.179	.036	.034	3	1
UCEC	PDCD4 →	-0.723	-3.000	<.001	.001	3	1
UCEC	Annexin-1 →	+0.665	+3.321	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by WNT3 expression — UCEC

Explore this box plot interactively →