WNT3

Across TCGA cell cohorts, WNT3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible WNT3-associated genes across cancer lineages are ARMH2, TLE7, and IFNA21. Each is linked with WNT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT3-to-partner and partner-to-WNT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARMH2 grouped by WNT3-low versus WNT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT3→partner) and Y-score (partner→WNT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARMH2 →	+0.221	+3.930	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.034	+4.969	<.001	.003	3	1
LUNG_NSCLC_LUAD	IFNA21 →	+0.038	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	TEX43 →	+0.127	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.012	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ARMH2 by WNT3 expression — LARGE_INTESTINE

Explore this box plot interactively →